TargetMol

Hemoregulatory peptide 5b

Product Code:
 
TAR-TP2340
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Hemoregulatory peptide 5b is a synthetic analog of granulocyte chalone which initially identified in extracts of rodent bone marrow and human leukocytes. Monomer inhibits both formations of GM-CFC colonies and cytotoxic drug-induced recruitment of murine CRU-S cells into the active cell cycle.
CAS:
84588-89-6
Molecular Weight:
604.63
Purity:
0.98
SMILES:
[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CS)=O)(NC([C@@H](NC(=O)[C@@H]1CCC(=O)N1)CCC(O)=O)=O)CC(O)=O

References

Paukovits JB, Rutter R, Ganglberger E, Karlic HI, Marian B, Paukovits WR. The hemoregulatory peptide pEEDCK may inhibit stem cell proliferation via hydropathic binding to antisense sequence motifs in interleukin-11 and other growth factors. Mol Pharmacol. 1999 Oct;56(4):665-74. PubMed PMID: 10496948. Karlic H, Louda N, Pfeilst?cker M, Keil F, Lohninger A, Pittermann E, Paukovits J. Effect of the hemoregulatory peptide (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 and MIP-1alpha is reduced in bone marrow cultures from patients with chronic myeloid leukemia (CML). Stem Cells. 2001;19(4):321-8. PubMed PMID: 11463952. Kreja L, H?g? P, Muller-B?rat N, Laerum OD, Sletvold O, Paukovits WR. Effects of a hemoregulatory peptide (HP5b) on erythroid and myelopoietic colony formation in vitro. Scand J Haematol. 1986 Aug;37(2):79-86. PubMed PMID: 3764340. Frostad S, Kalland T, Aakvaag A, Laerum OD. Hemoregulatory peptide (HP5b) dimer effects on normal and malignant cells in culture. Stem Cells. 1993 Jul;11(4):303-11. PubMed PMID: 8401253.