anti-NLRP3/NALP3 (mouse) mAb (Cryo-1)

Product Code:

AG-20B-0006

Product Group:

Primary Antibodies

Supplier:

AdipoGen Life Sciences

Host Type:

Mouse

Antibody Isotype:

IgG2b

Antibody Clonality:

Monoclonal

Antibody Clone:

Cryo-1

Regulatory Status:

RUO

Target Species:

Mouse

Application:

Western Blot (WB)

Shipping:

Blue Ice

Storage:

-20°C

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Code	Size	Price

AG-20B-0006-C100

100 ug

£360.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Alternate Names/Synonyms:

NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein

Concentration:

1mg/ml

EClass:

32160000

Form (Short):

liquid

Formulation:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Handling Advice:

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Immunogen:

Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).

Long Description:

Monoclonal Antibody. Recognizes mouse NLRP3/NALP3. Isotype: Mouse IgG2b. Clone: Cryo-1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

NCBI, Uniprot Number:

Q8R4B8

Package Type:

Plastic Vial

Product Description:

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Purity:

>95% (SDS-PAGE)

Source / Host:

Purified from concentrated hybridoma tissue culture supernatant.

Specificity:

Recognizes mouse NLRP3/NALP3.

Transportation:

Non-hazardous

UNSPSC Category:

Primary Antibodies

UNSPSC Number:

12352203

Use & Stability:

Stable for at least 1 year after receipt when stored at -20°C.

Documents

References

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes: E. Ydens, et al.; J. Neuroinfl. 12, 143 (2015) | Complement Mediated Activation of the NLRP3 Inflammasome and its Inhibition by AAV Mediated Delivery of CD59 in a Model of Uveitis: B. Kumar, et al.; Mol. Ther. (2018), doi: 10.1016/j.ymthe.2018.03.012 | Selective inhibition of the p38alpha MAPK?MK2 axis inhibits inflammatory cues including inflammasome priming signals: C. Wang, et al.; J. Exp. Med. 215, (2018) | Gut Microbes Egested During Bites of Infected Sand flies Augment Severity of Leishmaniasis Via Inflammasome-Derived IL-1beta: R. Dey, et al.; Cell Host Microbe. 23, 134 (2018) | Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy: F. Cano-Cano, et al.; Front. Immunol. 12, 632132 (2021)