AdipoGen Life Sciences

anti-Pyrin (human) pAb (AL196)

Product Code:
 
AG-25B-0020
Product Group:
 
Primary Antibodies
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
-20°C
Storage:
 
-20°C
 

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AG-25B-0020-C100100 ug£330.00
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Further Information

Alternate Names/Synonyms:
Marenostrin; MEFV
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Synthetic peptide corresponding to aa 2-29 (A2KTPSDHLLSTLEELVPYDFEKFKFKLQ29) of human pyrin.
Long Description:
Polyclonal Antibody. Recognizes human pyrin. Source: Rabbit. Applications: IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Pyrin regulates inflammation by interacting with the cytoskeleton. Pyrin may direct the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed. Defects in pyrin are the cause for Mediterranean fever.
NCBI, Uniprot Number:
O15553
Package Type:
Plastic Vial
Product Description:
Pyrin regulates inflammation by interacting with the cytoskeleton. Pyrin may direct the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed. Defects in pyrin are the cause for Mediterranean fever.
Purity:
Epitope-affinity purified.
Source / Host:
Rabbit
Specificity:
Recognizes human pyrin.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing: S. Papin, et al.; Cell Death Differ. 14, 1457 (2007) | Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation: S.L. Masters, et al. Sci. Transl. Med. 8, 332ra45 (2016) | A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of Pyrin and distinction to Familial Mediterranean Fever: F. Moghaddas, et al.; Ann. Rheum.Dis. 76, 2085 (2017) | Lack of Protein Prenylation Promotes Nlrp3 Inflammasome Assembly in Human Monocytes: O.P. Skinner, et al.; J. Allergy Clin. Immunol. 143, 2315 (2019) [KO validation] | Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients: F. Magnotti, et al.; EMBO Mol. Med. 11, e10547 (2019) | Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1beta production by inhibiting the uptake of crystals by macrophages: H. Cui, et al.; Biochem. Pharmacol. 188, 114580 (2021)