Fc (human):RANKL Soluble (mouse) (rec.)
Product Code:
AG-40B-0059
AG-40B-0059
Host Type:
Human
Human
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Shipping:
Blue Ice
Blue Ice
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-40B-0059-C010 | 10 ug | £220.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
Contact us for more accurate information.
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Further Information
Alternate Names/Synonyms:
TRANCE; ODF; OPGL; TNFSF11; CD254
Biological Activity:
Induces osteoclastogenesis of bone marrow-derived macrophages.
Concentration:
0.1mg/ml after reconstitution
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Mouse RANKL (aa 157-316) is fused at the N-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to mouse RANK. Purity: >95% (SDS-PAGE). RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
Molecular Weight:
~55kDa (SDS-PAGE)
NCBI, Uniprot Number:
O35235
Package Type:
Plastic Vial
Product Description:
RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
Purity:
>95% (SDS-PAGE)
Sequence:
Mouse RANKL (aa 157-316) is fused at the N-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
Specificity:
Binds to mouse RANK.
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
References
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland: M. Beleut, et al.; PNAS 107, 2989 (2010) | RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma: J. Faget, et al.; J. Thor. Oncol. 13, 387 (2018) | Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-kappaB: M. Lubrano di Ricco, et al.; Eur. J. Immunol. 50, 972 (2020)