ProSci

Survivin Antibody

Product Code:
 
PSI-2237
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
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Western blot analysis of survivin in mouse spleen tissue lysate with survivin antibody at 1 μg/mL.
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Immunohistochemistry of Survivin in mouse spleen cells with Survivin antibody at 10 #956;g/mL.
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Western blot analysis of survivin in mouse spleen tissue lysate with survivin antibody at 1 μg/mL.
Immunohistochemistry of Survivin in mouse spleen cells with Survivin antibody at 10 #956;g/mL.

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CodeSizePrice
PSI-2237-0.02mg0.02mg£150.00
Quantity:
PSI-2237-0.1mg0.1mg£449.00
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Further Information

Additional Names:
Survivin Antibody: API4, EPR-1, API4, IAP4, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4
Application Note:
mSurvivin antibody can be used for detection of survivin by Western blot at 1 μg/mL. An approximate 17 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
Background References:
  • Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3:917-21
  • Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, Altieri DC. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998;396:580-4
  • Kobayashi K, Hatano M, Otaki M, Ogasawara T, Tokuhisa T. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci USA 1999;96:1457-62 (WD1000)
Buffer:
Survivin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (83%)
Immunogen:
Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.

The immunogen is located within the last 50 amino acids of Survivin.
NCBI Gene ID #:
332
NCBI Official Name:
baculoviral IAP repeat-containing 5
NCBI Official Symbol:
BIRC5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
17 kDa
Protein Accession #:
NP_001159
Protein GI Number:
59859878
Purification:
Survivin Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
O15392
User NOte:
Optimal dilutions for each application to be determined by the researcher.