ProSci

CaBP8 Antibody

Product Code:
 
PSI-5861
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of CaBP8 in 3T3 cell lysate with CaBP8 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of CaBP8 in 3T3 cell lysate with CaBP8 antibody at (A) 1 and (B) 2 μg/mL.

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CodeSizePrice
PSI-5861-0.02mg0.02mg£150.00
Quantity:
PSI-5861-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
CaBP8 Antibody: CABP8, CABP8, Calcium-binding protein 8, Calneuron I, CaBP8
Application Note:
CaBP8 antibody can be used for detection of CaBP8 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
CaBP8 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
Background References:
  • Sokal I, Li N, Verlinde CL, et al. Ca2+-binding proteins in the retina: from discovery to etiology of human disease. Biochim. Biophys. Acta.2000; 1498: 233-51.
  • Haeseleer F, Imanishi Y, Sokal I, et al. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem. Biophys. Res. Commun.2002; 290:615-23.
  • Ikura M, Osawa M, and Ames JB. The role of calcium-binding proteins in the control of transcription: structure to function. Bioessays2002; 24:625-36.
  • McCue HV, Burgoyne RD, Haynes LP. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. Biochem. Biophys. Res. Commun.2009; 380:825-31.
Buffer:
CaBP8 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CaBP8 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CaBP8.

The immunogen is located within the first 50 amino acids of CaBP8.
NCBI Gene ID #:
83698
NCBI Official Name:
calneuron 1
NCBI Official Symbol:
CALN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_113656
Protein GI Number:
157743275
Purification:
CaBP8 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q9BXU9
User NOte:
Optimal dilutions for each application to be determined by the researcher.