Chemodex

CPM

Product Code:
 
CDX-D0042
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20 °C
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Chemical Structure
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Chemical Structure

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CDX-D0042-M05050 mg£248.00
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CDX-D0042-M250250 mg£1,084.00
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Further Information

Alternate Names/Synonyms:
7-Diethylamino-3-(4-maleimidylphenyl)-4-methylcoumarin
Appearance:
Yellow solid.
CAS:
76877-33-3
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3
InChiKey:
YGIABALXNBVHBX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 76877-33-3. Formula: C24H22N2O4. MW: 402.44. Synthetic. Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.
MDL:
MFCD00077334
Molecular Formula:
C24H22N2O4
Molecular Weight:
402.44
Package Type:
Vial
Product Description:
Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.
Purity:
>95% (HPLC)
SMILES:
CCN(CC)C1=CC2=C(C=C1)C(C)=C(C(=O)O2)C1=CC=C(C=C1)N1C(=O)C=CC1=O
Solubility Chemicals:
Soluble in DMSO, DMF, acetonitrile or chloroform.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) C.C. Chung; Assay and Drug Devel. Techn. 6(3), 361 (2008) | (2) O. Khersonsky et al.; ChemBioChem 7(1), 49 (2006) | (3) J.E.T. Corrie et al.; J. Chem. Soc. Trans. Perkin Trans. 1, 2975 (1994)