ProSci

Synaptotagmin Antibody

Product Code:
 
PSI-50-193
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Avian
  • Bovine (Cattle)
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Synaptotagmin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
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Western blot of rat cortex lysate showing specific labeling of the ~65k synaptotagmin protein.
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Western blot of rat cortex lysate showing specific labeling of the ~65k synaptotagmin protein.

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PSI-50-193-0.1mL0.1mL£686.00
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Further Information

Background:
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995). Recent studies indicate that synaptotagmin?s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002). It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006).
Background References:
  • Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic vesicle fusion in a Ca(2+) dependent manner. Trends Neurosci. Apr;18(4):177-83.
  • Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (2002) Ca2+ dependent synaptotagmin binding to SNAP25 is essential for Ca2+ triggered exocytosis. Neuron May 16;34(4):599-611.
  • Poskanzer KE, Fetter RD, Davis GW (2006) Discrete residues in the c(2)b domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Neuron Apr 6;50(1):49-62.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide corresponding to amino acid residues within the synaptotagmin I protein.
NCBI Gene ID #:
25716
NCBI Official Name:
synaptotagmin I
NCBI Official Symbol:
Syt1
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65
Protein Accession #:
P21707
Protein GI Number:
94730428
Purification:
Affinity Purified
Research Area:
Neuroscience
Swissprot #:
P21707
User NOte:
Optimal dilutions for each application to be determined by the researcher.