Further Information
NR1, MRD8, GluN1, NMDA1, NMDAR1, ABL, JTK7, GLURZ1, GRIN1, NMD-R1, NMDZ1, NMZ1
Western Blot: 1:500~1:1000
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
- Tyszkiewicz JP, et al. J Physiol. 2004 Feb 1; 554 (Pt 3): 765-777
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NMDAR1 (Ab-896) antibody was raised against a peptide sequence around aa.894~898 (R-R-S-S-K) derived from Human NMDAR1.
2902
glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
120 kDa
NP_000823.4
11496971
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Neuroscience
This antibody detects endogenous level of total NMDAR1protein.
Q05586