AdipoGen Life Sciences

anti-Caspase-11 (mouse) mAb (8A5)

Product Code:
 
AG-20T-0139
Product Group:
 
Primary Antibodies
Antibody Clonality:
 
Monoclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Flow Cytometry
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
-20°C
Storage:
 
-20°C
1 / 1
Western blot using anti-Caspase-11 (mouse), mAb (8A5) (Prod. No. AG-20T-0139) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
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Western blot using anti-Caspase-11 (mouse), mAb (8A5) (Prod. No. AG-20T-0139) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.

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AG-20T-0139-C100100 ug£290.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Caspase-11 (mouse); Protease ICH-3 (mouse)
Concentration:
1mg/ml
EClass:
32160000
Endotoxin:
<0.1EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant mouse caspase-11 (p20 fragment).
Long Description:
Monoclonal Antibody. Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot. Isotype: Rat IgG1kappa. Clone: 8A5. Applications: ELISA, FACS, IP, WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.
NCBI, Uniprot Number:
P70343
Package Type:
Plastic Vial
Product Description:
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.
Purity:
>95% (SDS-PAGE)
Specificity:
Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.