Suc-Leu-Tyr-AMC
Product Code:
AG-CP3-0017
AG-CP3-0017
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-CP3-0017-M005 | 5 mg | £40.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
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Further Information
Alternate Names/Synonyms:
Suc-LY-AMC; Proteasome Substrate; Calpain Substrate; Papain Substrate
Appearance:
Solid lyophilized powder.
CAS:
94367-20-1
EClass:
32160000
Form (Short):
solid
Handling Advice:
Avoid freeze/thaw cycles.Protect from light.
InChi:
InChI=1S/C29H33N3O8/c1-16(2)12-22(31-25(34)10-11-26(35)36)29(39)32-23(14-18-4-7-20(33)8-5-18)28(38)30-19-6-9-21-17(3)13-27(37)40-24(21)15-19/h4-9,13,15-16,22-23,33H,10-12,14H2,1-3H3,(H,30,38)(H,31,34)(H,32,39)(H,35,36)/t22-,23-/m0/s1
InChiKey:
RIYLNECMTVNMSO-GOTSBHOMSA-N
Long Description:
Chemical. CAS: 94367-20-1. Formula: C29H33N3O8. MW: 551.6. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Fluorogenic substrate for calpain and papain. Peptide substrate for Ti protease from E.coli. Excitation: 360nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
MDL:
MFCD00057900
Molecular Formula:
C29H33N3O8
Molecular Weight:
551.6
Other data:
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100µM.
Package Type:
Vial
Product Description:
Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Fluorogenic substrate for calpain and papain. Peptide substrate for Ti protease from E.coli. Excitation: 360nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
Purity:
>98% (TLC)
Sequence:
N-Succinyl-Leu-Tyr-7-amido-4-methylcoumarin
SMILES:
CC(C)C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NC1=CC2=C(C=C1)C(C)=CC(=O)O2
Solubility Chemicals:
Soluble in DMSO or methanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates: T. Sasaki, et al.; J. Biol. Chem. 259, 12489 (1984) | Na+, K+-specific inhibition of protein and peptide hydrolyses by proteasomes from human hepatoma tissues: J.H. Seol, et al.; FEBS Lett. 247, 197 (1989) | Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides: K.M. Woo, et al.; J. Biol. Chem. 264, 2088 (1989) | Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: implications for p53 ubiquitination: O.D. Reyes-Hernandez, et al.; Biochem. Pharmacol. 80, 932 (2010)