AdipoGen Life Sciences

Z-Leu-Leu-Glu-AMC

Product Code:
 
AG-CP3-0022
Product Group:
 
Other Biochemicals
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CP3-0022-M0011 mg£45.00
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AG-CP3-0022-M0055 mg£115.00
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Further Information

Alternate Names/Synonyms:
Z-LLE-AMC; Proteasome Substrate II
Appearance:
Solid lyophilized powder.
CAS:
348086-66-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.Protect from light.
InChi:
InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
InChiKey:
FOYHOBVZPWIGJM-KCHLEUMXSA-N
Long Description:
Chemical. CAS: 348086-66-8. Formula: C35H44N4O9. MW: 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (PGPH) (caspase-like) activity of the 20S proteasome. Excitation: 380nm. Emission: 460nm.
MDL:
MFCD01074989
Molecular Formula:
C35H44N4O9
Molecular Weight:
664.8
Other data:
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100µM.
Package Type:
Vial
Product Description:
Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (PGPH) (caspase-like) activity of the 20S proteasome. Excitation: 380nm. Emission: 460nm.
Purity:
>95% (HPLC)
Sequence:
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin
SMILES:
CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NC1=CC=C2C(C)=CC(=O)OC2=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor: T.L. Chang, et al.; Planta Med. 76, 987 (2010) | Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit: J. Blackburn, et al.; Biochem. J. 430, 461 (2010)