ProSci

IDO Antibody [ID 177]

Product Code:
 
PSI-36-036
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
ID 177
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-036-100ug100ug£524.00
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Further Information

Additional Names:
Indoleamine 2,3-dioxygenase; INDO
Application Note:
ELISA: (direct or indirect: 1:2,000-1:10,000). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.
Background:
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
Buffer:
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human IDO.
NCBI Gene ID #:
3620
NCBI Official Name:
indoleamine 2,3-dioxygenase 1
NCBI Official Symbol:
IDO1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
4504577
Protein GI Number:
NP_002155.1
Research Area:
Cancer,Immunology,Innate Immunity,Obesity
SPECIFICITY:
Recognizes human IDO. Detects a band of ~45kDa by Western blot. Other species not tested.
Swissprot #:
P14902
User NOte:
Optimal dilutions for each application to be determined by the researcher.