ProSci

IL-1alpha Antibody [Bamboo-2] (biotin)

Product Code:
 
PSI-36-166
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Bamboo-2
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-166-100ug100ug£686.00
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Further Information

Additional Names:
Interleukin-1alpha
Application Note:
ELISA: (as a detection antibody).
Background:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse mature IL-1alpha.
NCBI Gene ID #:
16175
NCBI Official Name:
interleukin 1 alpha
NCBI Official Symbol:
Il1a
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
124298
Protein GI Number:
P01582
Purification:
>95% (SDS-PAGE)
Research Area:
Apoptosis,Immunology,Innate Immunity
SPECIFICITY:
Recognizes mouse IL-1alpha.
Swissprot #:
P01582
User NOte:
Optimal dilutions for each application to be determined by the researcher.