ProSci

Tim-1 Recombinant Protein

Product Code:
 
PSI-90-547
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-547-100ug100ug£765.00
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Further Information

Additional Names:
TIM1, KIM1, TIMD1, Hepatitis A Virus Cellular Receptor 1, HAVcr-1, T Cell Immunoglobulin and Mucin Domain-containing Protein 1, T Cell Membrane Protein 1
Application Note:
This recombinant proteins is for research use only.
Background:
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-1 (KIM-1; HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of Tim-1. One is a long (359 aa) kidney form termed Tim-1b, and one is a short (334 aa) liver form termed Tim-1a. Tim-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
171283
NCBI Official Name:
hepatitis A virus cellular receptor 1
NCBI Official Symbol:
Havcr1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_001160104
Protein GI Number:
262231825
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
P23785

Documents