Further Information
Alternate Names/Synonyms:
CI1033; PD-183805
Solid.
267243-28-7
9
32160000
liquid
GHS05,GHS08,GHS09
H318, H373, H402
InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
OMZCMEYTWSXEPZ-UHFFFAOYSA-N
Chemical. CAS: 267243-28-7. Formula: C24H25ClFN5O3. MW: 486. Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
C24H25ClFN5O3
486
Plastic Vial
P280, P273, P260, P314, P305, P351, P338
Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
>95%
Danger
Soluble in DMSO or ethanol.
Non-hazardous
UN 3077
Protein Kinase Modulators
12352200
Stable for at least 2 years after receipt when stored at -20°C.