AdipoGen Life Sciences

MK-2461

Product Code:
 
SYN-1149
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
MK2461
Appearance:
Solid.
CAS:
917879-39-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
InChiKey:
JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Long Description:
Chemical. CAS: 917879-39-1. Formula: C24H25N5O5S. MW: 495.6. MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) values of 0.4 to 2.5nM.
Molecular Formula:
C24H25N5O5S
Molecular Weight:
495.6
Package Type:
Plastic Vial
Product Description:
MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) values of 0.4 to 2.5nM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor: B.S. Pan, et al.; Cancer Res. 70, 1524 (2010) | Tetraspanin-enriched microdomains regulate digitation junctions: C. Huang, et al.; Cell. Mol. Life Sci. doi.org/10.1007/s00018-018-2803-2 (2018)