Further Information
Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14, LOXL2
For WB starting dilution is: 1:1000
This gene encodes a member of the lysyl oxidase gene
family. The prototypic member of the family is essential to the
biogenesis of connective tissue, encoding an extracellular
copper-dependent amine oxidase that catalyses the first step in the
formation of crosslinks in collagens and elastin. A highly
conserved amino acid sequence at the C-terminus end appears to be
sufficient for amine oxidase activity, suggesting that each family
member may retain this function. The N-terminus is poorly conserved
and may impart additional roles in developmental regulation,
senescence, tumor suppression, cell growth control, and chemotaxis
to each member of the family.
- Rodriguez, H.M., et al. J. Biol. Chem. 285(27):20964-20974(2010)
- Ruckert, F., et al. IntColorectal Dis 25(3):303-311(2010)
- Schietke, R., et al. J. Biol. Chem. 285(9):6658-6669(2010)
- Sano, M., et al. Int. J. Oncol. 36(2):321-330(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse, Rat
This LOXL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-617 amino acids from the C-terminal region of human LOXL2.
4017
Lysyl oxidase homolog 2
LOXL2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Q9Y4K0
13878585
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
Q9Y4K0
Optimal dilutions for each application to be determined by the researcher.