Further Information
Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1
For WB starting dilution is: 1:1000
Proper cohesion of sister chromatids is a prerequisite for
the correct segregation of chromosomes during cell division. The
cohesin multiprotein complex is required for sister chromatid
cohesion. This complex is composed partly of two structural
maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2
or the protein encoded by this gene. Most of the cohesin complexes
dissociate from the chromosomes before mitosis, although those
complexes at the kinetochore remain. Therefore, the encoded protein
is thought to be an important part of functional kinetochores. In
addition, this protein interacts with BRCA1 and is phosphorylated
by ATM, indicating a potential role for this protein in DNA repair.
This gene, which belongs to the SMC gene family, is located in an
area of the X-chromosome that escapes X inactivation. [provided by
RefSeq].
- Limongelli, G., et al. Am. J. Med. Genet.152A (8), 2127-2129 (2010) :
- Homme, C., et al. Oncol. Rep. 24(1):47-56(2010)
- Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :
- Wong, R.W. Cell Cycle 9(1):198-200(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A.
8243
Structural maintenance of chromosomes protein 1A
SMC1A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
143 kDa
Q14683
29336622
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q14683
Optimal dilutions for each application to be determined by the researcher.