ProSci

Dsk2 Antibody

Product Code:
 
PSI-61-129
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody is used in Western blot to detect Dsk2 in HeLa cell lysate.
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Antibody is used in Western blot to detect Dsk2 in HeLa cell lysate.

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PSI-61-129-400ul400ul£626.00
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Further Information

Additional Names:
Ubiquilin-2, Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, PLIC-2, hPLIC-2, Ubiquitin-like product Chap1/Dsk2, UBQLN2, N4BP4, PLIC2
Application Note:
For WB starting dilution is: 1:1000
Background:
Dsk2 increases the half-life of proteins destined to be degraded by the proteasome, and may modulate proteasome-mediated protein degradation. The Dsk2 protein binds UBE3A and BTRC, and interacts with the 19S proteasome subunit. In the cytoplasm, Dsk2 colocalizes with the proteasome; it is also associated with fibers in mitotic cells in the nucleus. Dsk2 is highly expressed in mitotic cells from metaphase to telophase, while expression in non-mitotic cells is very low.
Background References:
  • Walters, K.J., et al., Biochemistry 41(6):1767-1777 (2002).
  • Kleijnen, M.F., et al., Mol. Cell 6(2):409-419 (2000).
  • Ueki, N., et al., Nat. Biotechnol. 16(13):1338-1342 (1998).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Dsk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-545 amino acids from the C-terminal region of human Dsk2.
NCBI Gene ID #:
29978
NCBI Official Name:
Ubiquilin-2
NCBI Official Symbol:
UBQLN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Protein Accession #:
Q9UHD9
Protein GI Number:
124056593
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle
Swissprot #:
Q9UHD9
User NOte:
Optimal dilutions for each application to be determined by the researcher.