Further Information
Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
This gene encodes a member of the peroxisome
proliferator-activated receptor (PPAR) family. PPARs are nuclear
hormone receptors that bind peroxisome proliferators and control
the size and number of peroxisomes produced by cells. PPARs mediate
a variety of biological processes, and may be involved in the
development of several chronic diseases, including diabetes,
obesity, atherosclerosis, and cancer. This protein is a potent
inhibitor of ligand-induced transcription activity of PPAR alpha
and PPAR gamma. It may function as an integrator of transcription
repression and nuclear receptor signaling. The expression of this
gene is found to be elevated in colorectal cancer cells. The
elevated expression can be repressed by adenomatosis polyposis coli
(APC), a tumor suppressor protein related to APC/beta-catenin
signaling pathway. Knockout studies in mice suggested the role of
this protein in myelination of the corpus callosum, lipid
metabolism, and epidermal cell proliferation. Alternate splicing
results in multiple transcript variants.
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Christopoulos, P., et al. Ann. N. Y. Acad. Sci. 1205, 185-191 (2010) :
- Dunn, S.E., et al. J. Exp. Med. 207(8):1599-1608(2010)
- Eynon, N., et al. Mitochondrion (2010) In press :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-394 amino acids from the C-terminal region of human PPARD.
5467
Peroxisome proliferator-activated receptor delta
PPARD
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Q03181
417522
This antibody is purified through a protein A column, followed by peptide affinity purification.
Obesity
Q03181
Optimal dilutions for each application to be determined by the researcher.