Further Information
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B
For WB starting dilution is: 1:1000
PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
- Xu, J., et al., Biochem. Biophys. Res. Commun. 329(2):538-543 (2005).
- Palmer, N.D., et al., Diabetes 53(11):3013-3019 (2004).
- Bento, J.L., et al., Diabetes 53(11):3007-3012 (2004).
- Wiesmann, C., et al., Nat Struct Mol Biol 11(8):730-737 (2004).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.
5770
Tyrosine-protein phosphatase non-receptor type 1
PTPN1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
P18031
131467
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Obesity,Signal Transduction
P18031
Optimal dilutions for each application to be determined by the researcher.