Chemodex

Paclitaxel

Product Code:
 
CDX-P0188
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
AMBIENT
Storage:
 
+4°C
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Chemical Structure
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Chemical Structure

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CDX-P0188-M01010 mg£72.00
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CDX-P0188-M05050 mg£169.00
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Further Information

Alternate Names/Synonyms:
Taxol; BMS 181339-01; NSC 125973
Appearance:
White to off-white powder.
CAS:
33069-62-4
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H341-H360-H371-H413
InChi:
InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChiKey:
RCINICONZNJXQF-MZXODVADSA-N
Long Description:
Chemical. CAS: 33069-62-4. Formula: C47H51NO14. MW: 853.91. Synthetic. Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor, immunostimulant and TRAIL sensitizer.
MDL:
MFCD00869953
Molecular Formula:
C47H51NO14
Molecular Weight:
853.91
Package Type:
Vial
Precautions:
P201-P260-P280-P308 + P313
Product Description:
Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor, immunostimulant and TRAIL sensitizer.
Purity:
>98%
Signal word:
Danger
SMILES:
O[C@](C(C)(C)C1=C(C)[C@H]2OC([C@@H]([C@H](C3=CC=CC=C3)NC(C4=CC=CC=C4)=O)O)=O)(C2)[C@H]([C@]([C@]([C@@H](O)C5)(C)C([C@@H]1OC(C)=O)=O)([H])[C@]6([C@]5([H])OC6)OC(C)=O)OC(C7=CC=CC=C7)=O
Solubility Chemicals:
Soluble in DMSO (50 mg/ml), methanol (50 mg/ml) or ethanol.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

(1) J.E. Liebmann, et al.; Br. J. Cancer 68, 1104 (1993) | (2) R. Foa, et al.; Int. J. Clin. Lab. Res. 24, 6 (1994) (Review) | (3) M. Woods, et al.; Mol. Med. 1, 506 (1995) | (4) A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) | (5) L.A. Amos & J. L?we; Chem. Biol. 6, R65 (1999) (Review) | (6) M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) | (7) T.H. Wang, et al.; J. Biol. Chem. 274, 8208 (1999) | (8) T.H. Wang, et al.; Cancer 88, 2619 (2000) | (9) T.M. Mekhail & M. Markman; Expert Opin. Pharmacother. 3, 755 (2002) | (10) A. Javeed, et al.; Eur. J. Pharm. Sci. 38, 283 (2009) (Review) | (11) D. Finlay, et al.;PLoS One 5, e13375 (2010) | (12) B. Ai, et al.; Am. J. Cancer Res. 6, 1624 (2016) (Review)