Recently 5 new B7 family ligands, B7-H3, B7-H4, B7-H5, B7-H6 & B7-H7, were identified, all of them possibly of high interest in immunotherapy research.
OX40 – OX40L Pathway
OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.
CD40 – CD40L Pathway
CD40 is a member of the TNF receptor family expressed by APCs and B cells whereas its ligand, CD40L (CD154), is expressed by activated T cells.
GITR – GITRL Pathway
Glucocorticoid-induced TNFR-related protein is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL.
CD137 – CD137L Pathway
CD137 is an activating receptor binding to CD137L, expressed on natural killer (NK) cells & T cells, therefore triggering innate & adaptive immunity.
Proteins with Enhanced Activity & Stability
AdipoGen Life Sciences specialises in the development of recombinant proteins that show enhanced activity and stability, produced in mammalian cells.
Poly(ADP-ribosyl)ation (PARylation) – An Important Posttranslational Modification
AdipoGen Life Sciences provide high quality reagents for PAR & PARP research
Popular Targets for Bispecific Antibody Drugs
Bispecific Antibody drugs gained popularity since approval of blinatumomab. 6 bsAb drugs are approved by the US FDA/EMA & 180+ are in clinical trials.
The Role of Monoclonal Antibodies & Biosimilars in Research – ProSci Inc.
With more than 800 Research Grade Biosimilar antibodies in ProSci’s catalogue, these unique tools are available for researchers worldwide. Explore the world of biosimilars! In 1986, the first monoclonal antibody became licensed–an event occurring nine years after the generation of
What is Leukapheresis?
Understanding Leukapheresis Leukapheresis is derived from the Latin words “leuk,” meaning white, and “aphaeresis,” meaning to take away. Put together, leukapheresis describes the collection of leukocytes — also known as white blood cells or immune cells — using a Spectra