BAFF Soluble (human) ELISA Kit (hypersensitive)

AdipoGen Life Sciences
Product Code: AG-45B-0001
Product Group: ELISA Kits

CodeSizePrice
AG-45B-0001-KI0196 wells£540.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
Blue Ice
Storage:
4deg;C

Images

1 / 1
Specificity

Specificity

Further Information

Alternate Names/Synonyms:
BlyS; B Cell Activating Factor
Assay Type:
Sandwich
Detection Type:
Colorimetric
EClass:
32160000
Handling Advice:
After standard reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Plate and reagents should reach room temperature before use.
Long Description:
ELISA Assay. Detects human BAFF. Does not detect mouse BAFF. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 15.6 - 500 pg/ml. Sensitivity: 8pg/ml. BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren?s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
NCBI, Uniprot Number:
Q5H8V1
Package Type:
Box
Product Description:
BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren?s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Range:
15.6 - 500 pg/ml
Sample Type:
Cell Culture Supernatant, Plasma, Serum
Sensitivity:
8pg/ml
Specificity:
Detects human BAFF. Does not detect mouse BAFF.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
12 months after the day of manufacturing. See expiry date on ELISA Kit box.

References

CVID-associated TACI mutations affect autoreactive B cell selection and activation: N. Romberg, et al.; J. Clin. Invest. 123, 4283 (2013) | Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011?2012 influenza vaccine season: D. Frasca, et al.; Immun. Ageing 10, 14 (2013) | Selective Activation of Human Dendritic Cells by OM-85 through a NF-kB and MAPK Dependent Pathway: C. Parola, et al.; PLOS One 8, e82867 (2013) | Innate lymphoid cells integrate stromal and immune signals to enhance antibody production by splenic marginal zone B cells: G. Magri, et al.; Nat. Immunol. 15, 354 (2014) | TACI expression and signaling in chronic lymphocytic leukemia: A. Mamara, et al.; J. Immunol. Res. 2015, 478753 (2015) | Increased BAFF and APRIL levels in the cerebrospinal fluid of patients with anti-neutrophil cytoplasmic antibody-related hypertrophic pachymeningitis: Y. Shimojima, et al.; Cytokine 99, 305 (2017) | Inhibition of membrane-bound BAFF by the anti-BAFF antibody belimumab: C. Kowalczyk-Quintas, et al.; Front. Immunol. 9, 2698 (2018) | B?cell profile, B?cell activating factor concentration and IgG levels in human cutaneous and mucosal leishmaniasis: C. Parodi, et al.; Parasite Immunol. e12759 (2020) | BAFF 60-mer, and differential BAFF 60-mer dissociating activities in human serum, cord blood and cerebrospinal fluid: M. Eslamy, et al.; Front. Cell Dev. Biol. ahead of print, (2020)