ProSci

CD3e Antibody [145-2C11] (APC)

Product Code:
 
PSI-98-562
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[145-2C11]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 1
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PSI-98-562-0.1mg0.1mg£505.00
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Further Information

Additional Names:
CD3 epsilon
Application Note:
CD3e Antibody [145-2C11] for use in flow cytometry assays.
Background:
CD3epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25 kDa epsilon chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and na?ve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL?s. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone BM10-37
NCBI Gene ID #:
12501
NCBI Official Name:
CD3 antigen, epsilon polypeptide
NCBI Official Symbol:
Cd3e
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P22646
Research Area:
Immunology
SPECIFICITY:
CD3epsilon
Swissprot #:
P22646
User NOte:
Optimal dilutions for each application to be determined by the researcher.