AdipoGen Life Sciences – Leading Supplier of Innovative Research Reagents for Inflammation & Immune Responses - Distributed in the UK & Ireland by Caltag Medsystems
AdipoGen Life Sciences
AdipoGen Life Sciences, Inc. (AGLS) has a specialised and comprehensive product portfolio comprised of proteins, antibodies (with a special focus on functional antibodies and recombinant antibodies) and ELISA kits.
They are experts on Inflammation & Immune Responses with products on the following research areas: inflammasomes, innate immunity, B & T cells immune regulation, neuroinflammation, obesity & metabolic diseases, immuno-oncology, and bacterial & viral infection.
AdipoGen also owns chemical laboratories, enabling them to isolate unique natural products and develop new and innovative small molecules and rare antibiotics.
AdipoGen Life Sciences also provides the brands Ancell, Chemodex, Chimerigen, Innaxon, JaICA, RevMAb and South Bay Bio.
See the Products Available:
Recombinant Proteins
Key Features of AdipoGen's Recombinant Proteins:
- Low endotoxin levels
- Produced in E. coli, HEK 293, CHO and Insect Cells
- Bulk quantities available
- Animal-Free components production (Serum-Free)
InVivoKines™ – Biologically Active Proteins with Enhanced Activity & Stability for in vivo Research
InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. InVivoKines™ are Fc-based fusion proteins using the Knobs-into-holes (KIH) technology.
- The KIH-Fc technology allows Fc heterodimerisation, which results in a structure with two different arms. This enables the creation naturally occurring active monomeric, heterodimeric or homodimeric proteins.
- The KIH-Fc domain enhances the plasma half-life of the cytokine which substantially improves the pharmacokinetics (PK) while maintaining activity.
- The KIH-Fc domain engages with the Fcγ receptors (FcγRs) and the complement C1q, which may result in Antibody-Dependent Cellular Cytotoxicity (ADCC), Antibody-Dependent Cellular Phagocytosis (ADCP) and Complement-dependent Cytotoxicity (CDC).
- The KIH-Fc LALA-PG mutations inhibit binding to FcγRs and C1q while FcRn binding, and Fc stability remain unaffected.
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InVivoKines™ Proteins with Enhanced Activity & Stability
B-Xpander™ – Unleash the Power of B Cell Expansion for Clinical Research & Immunotherapies
Interest in B cells has recently increased in immunotherapies using Engineered B cells or Tumour-Infiltrating Lymphocytes (TILs). However, current methods for B cell expansion are inefficient, time consuming and can lead to insufficient B cell numbers and persistent T cell exhaustion. AdipoGen's B-Xpander™ protein improves current protocols for B cell stimulation by mimicking the natural interaction between CD40L and CD40 molecules on B cells.
B-Xpander™ is a potent enhanced Multimeric human CD40L cytokine, for B cell activation, B cell expansion (proliferation) and cell therapy applications. AdipoGen's in-house production using a proprietary protocol and a characterised and certified CHO cell line allows the supply of the most active Multimeric human CD40L proteins in GMP-like format.
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Antibodies
Key Features of AdipoGen's Antibodies:
- Raised against purified native proteins
- Extensively tested/validated
- Cited in scientific publications
- Competent for different applications
- ATTO, Biotin and FITC-labelled
- Used in ELISA Kits
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Antibody Validation Fibronectin (EDA) PANoptosis
Functional Antibodies – FuncAbs™
Antibodies displaying an agonist or antagonist activity (functional grade antibodies (FuncAbs™)) are powerful tools for mimicking or blocking physiological functions in vitro and in vivo. Functional grade antibodies are available free of preservatives and tested for low endotoxin content and may be used for activation, neutralising or blocking studies, both in vitro or in vivo.
Read more about Functional Grade Antibodies
Recombinant Monoclonal Antibodies – RecMAbs™ – Produced with No Use of Animals
To promote the advancement of non-animal alternative approaches (3Rs), AdipoGen implemented the antibody phage display technology in-house to develop monoclonal antibodies without the use of animals.
Using this technology, AdipoGen was a forerunner in releasing the first recombinant monoclonal antibody for research on the market in 2010: anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1).
Since then, their portfolio of fully validated recombinant antibodies made with the phage display technology continues to grow, with a focus on functional antibodies that can block or activate their respective target.
Key Features of AdipoGen's RecMAbs™:
- Developed from a human antibody phage display library and produced in mammalian cells (CHO or HEK 293).
- Show similar properties compared to monoclonal antibodies developed in mice/rat/rabbit (e.g. affinity in the low nanomolar range).
- Ideal for conserved antigens (which are poorly immunogenic in animals) to detect conformational epitopes (e.g. GTP-bound proteins) or protein modifications (e.g. phosphorylations, ubiquitinations).
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RecMabs™ Non-Animal Source Antibodies
Inflammasome-Related Antibodies
AdipoGen Life Sciences provides unique antibodies for inflammasome research. These include, NLRP3 Inflammasome Starter Sets, antibodies for the specific detection of caspase-1 and various standard inflammasome signalling antibodies.
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ELISA Kits
AdipoGen Life Sciences develop and manufacture unique ELISA Kits for metabolic syndrome biomarkers (obesity/type 2 diabetes, insulin resistance, cardiovascular), inflammatory disease biomarkers (rheumatoid arthritis, neuroinflammation), cancer & autoimmune disease biomarkers and SARS-CoV/COVID-19 Research. They also provide ELISA Kits for preclinical and diagnostic research study biomarkers, such as Progranulins, Visfatin, Periostin, DLK-1 and BAFF.
Key Features of AdipoGen's ELISA Kits:
- High performance quality kits
- Reproducible results with low inter- and intra-assay variation
- High sensitivity and specificity
- Broad range of sample types (e.g. serum, plasma, cell culture supernatant, urine)
- Unique intracellular detection systems
- Many product-specific literature references
Read more about AdipoGen's ELISA Kits
Progranulin ELISA Kit
AdipoGen’s Progranulin (human) ELISA Kits are the only kits on the market detecting all mutations of Progranulin. They are both validated on Mutated and Null GRN plasma samples.
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Erythroferrone ELISA Kit
AdipoGen's Erythroferrone (human) ELISA Kit is a Sandwich assay based on two antibodies and is to be used for the in vitro quantitative determination of human Erythroferrone in cell culture supernatants, serum and plasma. Levels of Erythroferrone measured by this ELISA kit in serum and plasma correspond to mouse protein levels (~ 500 ng/ml).
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Small Molecules
AdipoGen Life Sciences' business division “Small Molecules/Biochemicals” supports the overall product portfolio in the key areas Inflammasomes & Innate Immunity, B & T Cells Immune Regulation, Immune Checkpoint Regulation, Neuroinflammation, Obesity/Metabolic Diseases and Bacterial and Viral Infection. AdipoGen Life Sciences is the manufacturer of many unique and high quality biochemicals and partners closely with Chemodex.
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Natural Products / Rare Antibiotics
AdipoGen Life Sciences provides key standard research antibiotics, rare metabolites/antibiotics with new chemical structures (often only described once in literature and afterwards lost to research) or old already forgotten substances for lead drug research, seeking new “antibiotics” with new mode of actions and new molecular targets. In addition, these substances can be used for in vitro or in vivo studies based on their biological activities or as standard secondary metabolites, important as chemo-taxonomic markers of microbial species.
Research Areas
Inflammasomes & Innate Immunity
AdipoGen Life Sciences is an expert in inflammasome research. Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation.
The hallmarks of inflammasome activation are the secretion of the mature forms of caspase-1 and interleukin-1β (IL-1β) from cells of the innate immune system.
Beneficial inflammatory responses arise by maintaining homeostatic tissue function (detection and repair of tissue damages after trauma or pathogen invasion). Among the harmful inflammatory responses are particle-induced sterile inflammation, caused by host-derived particles such as monosodium urate (MSU) crystals, as well as environmental and industrial particles such as asbestos, silica and metallic nanoparticles.
Accumulating evidence also implicates inflammasome activity in numerous other diseases, including cancer and the development of metabolic diseases (like type 2 diabetes, atherosclerosis), some neurodegenerative diseases (like Alzheimer's, Prion, Parkinson's), autoimmune diseases (such as multiple sclerosis) and inflammatory bowel diseases.
AdipoGen provides a large selection of research reagents targeted to the various components of the inflammasome, including the Gasdermin D signalling pathways, thanks to a long-term collaboration with the Professor Jurg Tschopp group - the team who discovered the inflammasome in 2002.
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Inflammasomes Gasdermin D Signalling Pathways
View NLRP3 Inflammasome Wallchart
AdipoGen also provides a large selection of research reagents targeted to the various components of the immune system. The innate immune system plays an essential role in the host's first line of defence against microbial invasion and involves the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing of danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs).
Read more about Innate Immunity
View Pattern Recognition Receptors Wallchart
B & T Cells Immune Regulation / Immune Checkpoints / Immuno-oncology
TNF Superfamily – Key Cytokines in B & T cell Immuno-Regulation
TNFSF/TNFRSF together with the CD28-B7 family are two major co-signal pathways in T cell activation. CD28, ICOS, GITR, 4-1BB and OX40 pathways co-stimulate T cell activation. CTLA-4, PD-1, BTLA and CD160 pathways co-inhibit T cell activation. The B cell-stimulating molecules, APRIL and BAFF and critical factors in the maintenance of the B cell pool and humoral immunity.
Read more about the TNF Superfamily
View TNF Superfamily Wallchart
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Immune Checkpoint Reagents: Focus on T Cells
Cancer immunotherapy (also called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving the system’s natural ability to fight cancer. Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. Inhibitory checkpoint molecules, such as CTLA-4, PD-1, PD-L1 or LAG-3 are targets for cancer immunotherapy due to their potential for use in multiple types of cancers. AdipoGen Life Sciences offers a broad panel of immune checkpoint reagents, including recombinant proteins, antibodies, and ELISA Kits.
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Neuroinflammation
AdipoGen offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes a broad range of Irisin-related reagents, IL-33 reagents, the best inflammasomes research reagents to study the activation of neuroinflammation, posttranslational microtubule-specific antibodies, unique progranulin ELISA Kits and proteins, a broad range of immunometabolism reagents, biologically active Netrin-1 for axon outgrowth studies, many Neurochemicals, a selected range of neuronal dyes and stain, and many other reagents.
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Obesity & Metabolism
Obesity & Diabetes
Obesity is a major public health issue that is on the rise worldwide. It is estimated that over 1.0 billion adults are overweight or obese and this number is expected to continue to grow. Obesity is a risk factor for many chronic diseases, including heart disease, stroke, type 2 diabetes and some types of cancer. It is also a major cause of disability and premature death. Obesity research is essential and requires long-term investments to develop effective treatments and prevention strategies for this complex disease.
The blazing success of weight loss drugs like Wegovy and Mounjaro has electrified obesity research and especially the pursuit of new treatments for obesity. Dozens of companies are jumping into the race to market medications that are oral, longer-lasting, avoid side effects or provide additional benefits besides weight loss. Many of these drugs are targeting glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide (GIPR) and glucagon receptor (GCGR), as well as other hormones involved in satiety and metabolism; some are using entirely novel mechanisms.
AdipoGen Life Sciences provides a wide range of products for obesity research, including adipokine ELISA kits, obesity-related proteins & antibodies (including GDF15 proteins), Fibroblast Growth Factor products, PPAR reagents, metabolic research modulators, GLP-1, GIP & GCG receptor agonists and much more.
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GDF15 – an Exercise-induced Factor regulating Appetite & Energy Expenditure GLP-1, GIP & GCG in Obesity & Type 2 Diabetes Research
Immunometabolism Research
Immunometabolism is a research field that provides new insights into the dynamic crosstalk between the immune system (immunity) and metabolic processes of an organism (metabolism).
AdipoGen Life Sciences offers a broad range of Cell Metabolism and NAD+ Metabolism Reagents:
- Small Molecules Modulators of Glycolysis, TCA Cycle, Fatty Acid Oxidation, Fatty Acid Synthesis Pathway, Amino Acid Pathways
- Inhibitors of IDO1 and Nampt
- Biologically Active Enzymes: Human Arginase I / Human IDO1 Enzyme / Mouse Nampt
- FNDC5/Irisin not only plays a vital role in energy metabolism but also has crucial roles in a variety of processes such as inflammation, proliferation, metastasis, ageing and neural differentiation.
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View Cell Metabolism Research Wallchart
COVID-19
AdipoGen Life Sciences is a leading manufacturer of COVID-19 related products for:
- the qualitative detection of anti-SARS-CoV-2 IgG in serum and plasma.
- validating SARS-CoV-2 immune response.
- discovering biological or chemical agents that are inhibiting the binding of SARS-CoV-2 Spike Protein (RBD) to its human receptor ACE2
- the quantitative detection of soluble ACE2 levels in serum, plasma, urine and cell culture supernatants.
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More AdipoGen Brands
