ORF Genetics - Animal-Free, Endotoxin-Free Recombinant Proteins - Distributed in the UK & Ireland by Caltag
Founded in 2001, ORF Genetics is a global leader in the production of bioactive, animal-free recombinant Growth Factors and Cytokines, leveraging their proprietary production technology to build the Premium ISOkine product range.
ORFEUS, ORF Genetics’ unique expression system, uses barley grain as a vehicle for large-scale, recombinant protein production, providing a more efficient and safer method than other protein expression systems. The barley is grown in their own ISO 9001:2015-certified facility, located in a black lava field on the Reykjanes Peninsula, using Iceland’s rich, geothermal, renewable energy resources.
See the Products Available:
ISOkine Recombinant Proteins
The ISOkine product line features highly purified, endotoxin-free recombinant Human and Mouse Growth Factors and Cytokines, developed specifically for stem cell and cell-based therapies research, regenerative medicine, and organoid production.
Unparalleled Safety and Purity
- Animal Origin-free (AOF) and Animal Component-Free (ACF) – produced using a plant-based platform with barely seeds.
- Contaminant and biorisk-free – free of antibiotics, pyrogens and pro-inflammatory components, bacteria, viruses, and prions and are eukaryotic folded and glycosylated.
- Endotoxin-free – industry-leading endotoxin levels [<0.005 ng per µg (0.05 EU/µg)] to prevent unwanted cell responses.
Proven Performance and Quality
- Manufactured under ISO 9001:2015 – validated processes, comprehensive documentation and stringent quality measures.
- Up to 6 years shelf life – longest expiration dates in the industry.
- Biological activity comparable or superior to competitors – each batch tested by independent third-party companies.
- >95% purity, with lot-to-lot reproducibility.
Tailored Applications
- Stem Cell Research – for expansion, differentiation, and characterisation of human immune cells.
- Regenerative Medicine – compliant with regulatory guidelines for ancillary materials in clinical manufacturing processes.
- Diagnostics – reliable immunoassay controls.
- Preclinical Studies – research use only, but ideal for bridging the gap to GMP-grade products for clinical applications.
ORF Genetics are continually developing their ISOkine range, adding more growth factors and cytokines.