Leinco Technologies Inc. - In vivo antibodies, isotype controls, biosimilars and more. Distributed in the UK & Ireland by Caltag Medsystems

Leinco Technologies Inc.

Leinco Technologies is a biotechnology company founded in 1992 as a specialty manufacturer of early discovery research products including antibodies, recombinant proteins, ELISA kits, second-step reagents, and other life sciences products.

Shortly thereafter, they also established themselves as a premier provider of custom Research & Development and manufacturing services focusing on monoclonal antibodies and recombinant proteins.

Their innovative products and services are used to augment the early discovery process in life science research, diagnostics, and groundbreaking development of protein therapeutics.

Leinco's In Vivo Functional Grade Antibodies – In vivo GOLD™ and In vivo PLATINUM™

In vivo antibodies from Leinco serve the purpose of research applied in living animals or cells, for cell depletion, activation, neutralisation, blocking & many more.

Leinco Technologies has developed proprietary methods for manufacturing in vivo functional grade antibodies with the highest purity standards in the industry. The two quality standards of in vivo antibodies are: In vivo GOLD^TM and In vivo PLATINUM^TM.

In vivo GOLD^TM antibodies contain no preservatives, stabilisers or carrier proteins and have a low endotoxin level of ≤ 1.0 EU/mg.

Leinco's in vivo PLATINUM™ antibodies have the most stringent quality specifications for purity, endotoxins, aggregates, and leachable protein A. In vivo PLATINUM^TM antibodies have a low endotoxin level of ≤ 0.5 EU/mg. Each antibody is available in custom concentrations and package sizes. In vivo PLATINUM™ antibodies are also pathogen free and tested by the IDEXX Impact I PCR mouse pathogen profile.

Find out more about In vivo GOLD^TM and In vivo PLATINUM^TMantibodies

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Leinco's Isotype Control Antibodies

Leinco Technologies manufactures ultra-pure isotype control antibodies with the highest purity specifications available for in vivo preclinical studies, diagnostic assay controls or research assay controls. They also offer high purity immunoglobulins, purified from normal animal serum for use in a variety of assay applications. Most of these isotype control antibodies are also conjugated to a wide range of fluorescent dyes or enzymes.

Find out more about Isotype Control Antibodies

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Leinco's Primary Antibodies for oncology, neuroscience, immunology, apoptosis and other

Leinco Technologies manufactures an extensive range of primary antibodies for scientists to assure the level of their research is world class and generates reliable data for publications.

Leinco's antibodies have the highest purity specifications available in the research products industry and each lot produced is validated for specificity and clone identity.

Leinco offers primary antibodies for research in oncology, neuroscience, immunology, apoptosis, signal transduction and many other research areas of interest.

Find out more about Monoclonal vs. Polyclonal Antibodies

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Leinco Technologies has a growing range of recombinant chimeric antibodies, mAbMods™, which offer many advantages over those produced from traditional hybridoma technology.

Find out more about Recombinant Chimeric Antibodies

See all mAbMods™ here

Leinco's Secondary Antibodies

Leinco Technologies offers a wide range of second step reagents including secondary antibodies, streptavidin and UltraAvidin™, a deglycosylated form of avidin. Leinco applies its 35 plus years' experience in conjugation chemistry to manufacture a wide spectrum of fluorescent and enzyme conjugates for use in a variety of applications such as IHC, fluorescent microscopy, flow cytometry, western blotting, ELISA, and other applications.

Find out more about Secondary Antibodies

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Leinco's PhenoCycler-Fusion (CODEX)^® Spatial Biology reagents and services

Leinco Technologies is your go-to source for PhenoCycler-Fusion (CODEX)^® reagents and services. The PhenoCycler-Fusion (CODEX)^® imaging technology for spatially resolved, highly multiplexed biomarker analysis is from Akoya Biosciences.

Leinco provides high quality barcoded antibodies ‘Ready to Stain', reporter molecules (fluorophore-conjugated oligonucleotides) & PhenoCycler-Fusion validated antibodies.

PhenoCycler-Fusion (CODEX)^® ‘Ready to Stain' antibodies are validated according to tissue preparation, such as fresh frozen (FF) or fresh frozen paraffin-embedded (FFPE), and by tissue screened, such as liver, spleen, tonsil, brain, etc.

PhenoCycler-Fusion (CODEX)^® Barcoded Antibodies

Ready-to-use high quality PhenoCycler-Fusion (CODEX)^® barcoded antibodies and complementary fluorophore-conjugated oligonucleotides are available for spatial biology experiments. All DNA barcoded antibodies for PhenoCycler-Fusion (CODEX)^® have undergone multiple levels of validation and verification to assure conjugated antibodies are free of unconjugated antibodies and DNA barcodes.

Fluorophore reporter molecules are conjugated to complementary oligonucleotides and matched with barcoded antibodies. The four distinct fluorescent reporter molecules include Alexa Fluor™ 488 (green channel), Alexa Fluor 647 (far-red channel), Alexa Fluor 750 (infrared channel), and Atto 550 (yellow channel).

PhenoCycler-Fusion (CODEX)^® Validated Antibodies

Leinco Technologies offers purified PhenoCycler-Fusion (CODEX)^® Ready antibodies that are "Ready to Conjugate" to oligonucleotides (barcodes). These antibodies are formulated in conjugation ready buffers to minimise the antibody preparation needed when performing a PhenoCycler-Fusion (CODEX)^® barcode conjugation.

What is Spatial Biology?

Find out more about PhenoCycler-Fusion (CODEX)^® Technology and Workflow Steps

See all PhenoCycler-Fusion (CODEX)^® Barcoded Antibodies

See all PhenoCycler-Fusion (CODEX)^® Validated Antibodies

Leinco's Biosimilars

Leinco Technologies is a leader in the development and manufacturing of recombinant antibodies for early discovery research and diagnostics. They offer an extensive line of recombinant biosimilar antibodies at the in vivo functional purity levels you know and trust from Leinco Technologies. Recombinant biosimilar antibodies are designated for research use only and may not be used for therapeutics. Their biosimilars are made available to researchers to avoid purchasing therapeutic antibodies at pharmaceutical prices for important groundbreaking experiments.

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Leinco's Antibodies by Research area: Infectious Diseases, Immune Checkpoints, Neuroscience

Infectious Diseases

Infectious diseases have been causing epidemics in our communities since ancient times. Since its rise in early 2020, COVID-19 has affected every person in one way or another and does not seem to be stopping anytime soon. COVID-19 is not alone in its category. There are a multitude of infectious diseases that are equally as capable (in particular, viral diseases) continuing to emerge.

Leinco Technologies understands that research is critical to understanding and managing these diseases. Their infectious disease antibodies and proteins catalogue includes monoclonal and polyclonal antibodies and a range of recombinant proteins to help advance your infectious disease research.

See all Infectious Disease Antibodies

See all Infectious Disease Proteins

Immune Checkpoints

Leinco Technologies offers a wide range of well-known immune checkpoint antibodies for use in cancer research. Leinco is the premier manufacturer of in vivo functional grade antibodies with the highest purity specifications available. When conducting immune checkpoint preclinical research, it is important to use high purity in vivo grade antibodies to generate reliable data.

Leinco Technologies offers both GOLD™ and PLATINUM™ In vivo functional grade antibodies to important checkpoint markers for use in checkpoint research.

Find out more about Immune Checkpoints

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Neuroscience

The nervous system is responsible for a portion of nearly everything we do, from coordinating our bodily functions to our own consciousness. Studying the basics of how this system works can help develop treatments for debilitating neurological, psychiatric, and neurodegenerative disorders such as Alzheimer's disease, epilepsy, depression, schizophrenia, ALS, and neuro-oncology.

When studying neuroscience, researchers examine the role of nearly every type of cell and tissue in the body, as well as how this vast network interacts. To understand the complex and nuanced role of the many different cell types and tissues are involved, it is critical that researchers have dependable reagents that can generate reproducible and high quality science.

Leinco produces antibodies with the most stringent quality standards in the industry, providing unmatched reliability for your most important in vitro and in vivo neuroscience assays.

See all Neuroscience Antibodies

Leinco's Recombinant Proteins

Leinco has built a reputation on providing researchers with biologically active recombinant proteins, from a variety of host cells, that produce reliable research data. Leinco often selects mammalian expression systems using Chinese Hamster Ovary (CHO) or Human Embryonic Kidney (HEK) cells as the host to achieve the highest level of biological activity.

In addition, Leinco provides custom services to express and purify any protein you may require to conduct world-class research. They can also help scale up your expression system and purification by providing you with bulk, custom packaged proteins.

Leinco also offer monoclonal and polyclonal antibodies for most proteins. They are all produced in an animal-free, cGMP-compliant facility under their ISO quality system.

Leinco's Protein Specifications:

>95% Purity for most proteins
Longer storage and stability
Bulk proteins re-assayed to assure high biological activity
All proteins are Carrier Free/Low Endotoxin

Find out more about Recombinant Proteins

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Leinco's IVD Raw Materials

Matched Pairs

The development of in vitro diagnostics (IVD) kits based on immunoassays, such as lateral flow tests (LFT) and enzyme-linked immunosorbent assay (ELISA) relies on the availability of high-quality matched pairs of antibodies to capture and detect target analytes. It can be a challenge to find off-the-shelf and confirmed antibody pairs with the high sensitivity, specificity, purity, and stability needed to ensure an IVD kit meets performance requirements. Leinco has taken the guesswork out of finding antibodies for diagnostic raw materials, offering only the best-confirmed pairs.

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Antigens & Conjugates

Antigens and hapten conjugates are critical components of IVD diagnostic tests and are necessary to show that a test is both sensitive and specific. They often serve as positive controls for lateral flow tests and ELISA to ensure that a test is working correctly and that the antibodies used detect the molecules of interest. Incorporated for standard curve generation, they provide a reference for determining the concentration of targets of interest.

To be used in IVD test, all components must have exceptional purity and lot-to-lot reproducibility, and in the case of many antigens, may need to retain their function. All products from Leinco are manufactured in world-class facilities including in dedicated class 10K cleanrooms. Their manufacturing processes adhere to current Good Manufacturing Practices (cGMP's) and the ISO 9001:2015 or ISO 13485:2016 quality standards.

See all IVD Antigens & Conjugates

Assay Buffers

Leinco manufactures a range of high-quality assay reagents including substrates, coating buffers, blocking buffers, wash buffers and stop solutions. 30 years in the life science industry has allowed Leinco to accumulate a great deal of assay development knowledge.

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Secondary Antibodies & Controls

Leinco Technologies offers a wide range of second step reagents including secondary antibodies, streptavidin and UltraAvidin™, a deglycosylated form of avidin. Leinco then uses its 35+ years' experience in conjugation chemistry to manufacture a wide spectrum of fluorescent and enzyme conjugates for use in a variety of applications such as IHC, fluorescent microscopy, flow cytometry, western blotting, ELISA and more.

See all Secondary Antibodies

Custom Services

Leinco Technologies offers a variety of custom services, including:

Caltag Medsystems is here with you every step of the way to support your custom project with Leinco Technologies. To find out more, please contact us.

Category	Title
Antibodies Documents	Low Endotoxin in vivo Functional Grade Antibodies	View
With their ability to activate, neutralize or block the activity of their antigen, these antibodies are powerful tools for elucidating the function of a specific protein as well as interrogating the physiological impact of disrupting the proteins normal function. Leinco antibodies are suitable for numerous areas of research.
Antibodies (Biosimilars) Documents	Recombinant Human Biosimilar Antibodies	View
Research-grade active and FC-mutedTM biosimilars with best-in-class quality.
Citations Documents	Meeting the Need for High-Purity Research-Grade Biosimilars	View
Research-grade biosimilars have been developed as reagents to avoid the necessity of sourcing expensive therapeutic antibodies that are only available in large quantities. These non-therapeutic, recombinantly-expressed antibodies have the same variable region sequence as the corresponding therapeutic antibody, together with a human IgG constant region.
Citations Documents	Screening for Flu A Nucleoprotein Match Pairs for Rapid Lateral Flow Devices	View
Study using Influenza A IgG antibodies from Leinco Technologies, Inc.
Citations Documents	Improving the Cost-Efficient Generation of Reproducible Data In Immuno-Oncology Studies	View
This case study compares PD-1, PD-L1 and CTLA4 antibodies from Leinco Technologies vs a competitors products in a series of in vivo mouse experiments. The objective of the study was to evaluate the in vivo efficacy of the various clones on tumor growth and tolerability.
Citations Documents	Evaluation of Monkeypox Antibody Clones	View
In this study, three antibody clones available from Leinco Technologies (Table 1) were tested for their ability to bind and visualize mpox virus in cell cultures. The work was performed in the lab of Dr. John Connor <http://www.connorlab.com/>, which focuses on understanding how the virus-host interaction works and methods to tip the balance in favor of the host. To do this they aim to determine how viruses hijack infected cells, and how cells defend themselves against viral infection.
Immunology Documents	Matched Pair Infectious Disease Antibodies & Proteins For IVD	View
Leinco Technologies understands the need for reliable, high-performance IVD critical raw materials such as antibodies, proteins, and buffers. Our infectious disease antibodies and proteins catalog includes confirmed matched pairs for ELISA and Lateral Flow applications as well as cutting-edge recombinant antibodies with high specificity and sensitivity. We also offer recombinant antigens and blocking peptides to advance your infectious disease research.
Immunology Documents	Immunology: Mouse Neutralizing and Blocking Antibodies	View
Lot-to-lot reproducible monoclonal antibodies against mouse cell-specific proteins and cytokines are paramount for reproducible results. Depletion can occur naturally or be induced for treatment purposes. Therefore, it is a useful tool in therapeutic, immunotherapy and diagnostic research. It is common practice for researchers to use antibodies to remove a specific cell type to infer its function and mouse cell depletion in vivo experiments are used to establish the role of specific cell types in a variety of immunological processes. Many of these antibodies have been developed by academic and government labs all over the world and have been reported and referenced for use in in vivo studies to deplete a specific cell type.
Antibodies Documents	mAbModsTM Chimeric Anti-Mouse Antibodies	View
mAbMods™ recombinant antibodies have been engineered to have identical antigen binding variable domains to those of the traditional clones from which they are derived, but the IgG constant regions have been engineered to be of mouse origin. This reduces immunogenic responses in the mouse which can lead to adverse immunological reactions and gradual loss of activity.
Cancer Documents	Cancer Research: Mouse Immune Checkpoint and Related Proteins	View
Consistent and reliable antibodies targeting mouse immune checkpoints and related proteins are essential for advancing cancer research. Achieving lot-to-lot reproducibility is crucial for maintaining the integrity of scientific studies. Leinco Technologies offers a range of functional grade antibodies and is known for our exceptional lot-to-lot reproducibility, minimal endotoxin levels, and absence of detectable impurities. With these high-quality antibodies, researchers can confidently conduct in vivo studies to further our understanding of cancer immunotherapy.

Leinco Technologies Inc. - In vivo antibodies, isotype controls, biosimilars and more. Distributed in the UK & Ireland by Caltag Medsystems