3D Bio-Tissues - Pioneering novel bio-inspired manufacturing processes - Distributed by Caltag Medsystems
3D Bio-Tissues (3DBT)
A biotech startup spun out from Newcastle University in 2019, 3D Bio-Tissues (3DBT) is at the forefront of producing bio-equivalent tissues for clinical and cellular agriculture, applying novel bio-inspired manufacturing processes to generate complex structures.
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City-Mix™
A patented, non-toxic culture media supplement that acts as an effective "cell booster".
City-Mix™ is composed of a specific formulation of inert, food-safe, and bio-sustainable macromolecules with the unique capacity to mimic naturally crowded environments and highly efficient bioprocesses within living organisms.
By occupying space within aqueous solutions, macromolecular crowders create volume-exclusion effects shown to enhance the thermodynamic activity and stability of biomolecules such as proteins. This means that City-Mix™ can effectively boost the performance of a wide variety of cell cultures by promoting the bioactivity and/or bioavailability of growth factors, protein carriers, and enzymes contained within the culture medium.
By mimicking the in vivo environment several important changes in cell behaviour are observed, namely:
- Cellular proliferation rates increase, significantly increasing yield.
- Less supplements are required, reducing the need for expensive growth factors and recombinant proteins.
- Facilitates tissues production via extracellular matrix establishment.
- Helps reduce or eliminate the need for animal-derived ingredients (e.g., FBS, albumin) while maintaining media performance.
Shanghai-Mix™
Shanghai-Mix™ is a versatile cell booster for enhanced cell and tissue growth, effective in both serum-free or serum-containing media with applications in Myoblasts, Adipocytes and Fibroblasts.
Singapore-Mix™
Singapore-Mix™ is a good all-round macromolecular crowder, particularly effective for enhanced fat cell growth and for increased production of connective tissue with applications in Adipocytes, Myoblasts and Fibroblasts.
Tokyo-Mix™
Tokyo-Mix™ is a low-viscosity cell booster, that is particularly effective for enhanced stem cell proliferation with applications in ASC/MSCs.
London-Mix™
London-Mix™ is a supplement for enhanced extracellular matrix production with applications in Fibroblasts, Myoblasts and Adipocytes.
Miami-Mix™
Miami-Mix™ is a cell booster used to control spontaneous cell differentiation occurring in serum-free conditions with applications in Myoblasts, Adipocytes and Stromal Cells.
