Metatissue - Human-Based Matrices for Cell Culture and Tissue Engineering - Distributed in the UK & Ireland by Caltag Medsystems
Metatissue
Metatissue® was founded in 2018 by bringing together expertise from the COMPASS Research Group from CICECO, University of Aveiro.
They are focused on chemically modified human-derived proteins for the preparation of hydrogels, sponges and bioinks to improve 3D cell culture, disease modelling for drug development and personalised medicine advancements. Their solutions were conceived to create predictive and truly translatable 3D biological in vitro models.
Their technology’s potential to reduce or completely replace the use of animals for biological screenings will have a significant impact on the 3D cell culture market and pharmaceutical industry. Through the use of Metatissue’s platforms, only the most relevant drug candidates move forward to currently inefficient clinical trials. This is a cost-effective solution by significantly reducing wasted time and resources, alongside supporting animal welfare.
Methacryloyl Platelet Lysates (hPLMA)
hPLMA is a methacrylated bioactive platelet-rich plasma derivative precursor from donated human blood that can be crosslinked, upon light exposure, to form soft materials with tuneable mechanical properties.
The precursor solution is easily prepared by reconstituting hPLMA lyophilisate in an aqueous solution with a photoinitiator. Afterwards, it can be cured upon light exposure to form a hydrogel with tuneable mechanical properties.
hPLMA Photopolymerisable hydrogels provide great control over gelation time and matrix stiffness, enabling you to create the cell culture environment that better fits your project’s needs.
Features:
- Human-derived
- Reproducible
- Personalised
- Mechanically tuneable
Benefits:
- Animal-free
- Versatile
- Easy to Use
How to use
hPLMA Applications
3D Cell Culture
Cancer Research
Disease Modelling
Stem Cell Research
Tissue Engineering
3D Cell Culture
Cell Encapsulation in Hydrogels
Encapsulated stem cells maintain their viability for at least 7 days and are able to proliferate inside the hydrogels.
Cell Encapsulation in Sponges
Cell viability and proliferation without supplementation.
Stem cells cultured in hPLMA sponges maintain their viability up to 14 days without the need to use animal-derived serum supplements for cell culture media.
Tissue Engineering and Disease Modelling
Cell Invasion and Proliferation
Different cell lines present different invasiveness ability, reflected in hPLMA hydrogels and present a better performance than the animal-derived platform counterpart.
Validated Cells
