UK and Ireland Distributor of MBL International - Antibodies, Assay Kits, Tetramers and Reagents for Life Science Research and Clinical Diagnostics

MBL

Established in 1993, MBL International Corporation (MBLI) is a leading life science company focused on providing high quality, innovative, solutions-based products for both life science research and clinical diagnostics. Their products are used widely in academic research institutions, pharmaceutical and biotechnology companies, government agencies as well as hospital and reference laboratories.

The MBLI product range can be divided into five distinct categories:

Life Science Research

General Reagents

MBLI develops, manufactures, and markets a broad portfolio of monoclonal and polyclonal antibodies, fluorescent and recombinant proteins and ELISA kits for research related to allergy, apoptosis, autophagy, cancer, epigenetics, immunology, and neuroscience.

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MHC Tetramers: Directly Measure Antigen-Specific T Cells

MBLI has a wide portfolio of immune monitoring research products including tetramer technology for vaccine development, rapid T-cell detection and quantification in the pharmaceutical industry or bioresearch industry.

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Drug Discovery Tools

MBL International Corporation offers fluorescent protein-based drug discovery tools for use in living cells. Their novel technology, Fluoppi, can visualise Protein-Protein Interaction (PPI) of interest in living cells. Moreover, other product offering such as Keima-Red and FUCCI, can visualise autophagy/mitophagy and cell cycle respectively. These technologies are applicable for cell-based high-throughput drug screening.

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Clinical Diagnostics

Detection of Autoimmune Diseases

Autoimmune diseases are classified into systemic autoimmune disease and organ-specific autoimmune disease. MBLI offers a wide variety of ELISA and immunofluorescence assays (IFA) for the detection of disease-related autoantibodies including anti-nuclear antibodies and anti-desmosomal structural protein antibodies.

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Blog posts

Atg12 Binding Cascade: Cross-talk Between Apoptosis and Autophagy

MBLI's autophagy reagents include important targets such as LC3, p62/SQSTM1, ATG12, ATG14, ATG16L, ATG9, ULK1, and more.

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Why is the MHC monomer the ideal choice for your experimental design?

The MHC Monomer is a sub-component of an MHC Tetramer. Biotinylated Monomers are available for most associated Tetramer products.

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Flexibility and Expansion with BV421 Tetramers

Adding another marker to a flow cytometry panel can present a challenge when trying to accommodate all markers of interest in one panel. However, there is a solution.

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AMP-activated protein kinase (AMPK) Role in Cancer and Metabolic Diseases

MBL International’s AMPK kinase assay kit can be used to measure the activity of AMPK, a cellular energy sensor.

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QuickSwitch™ Quant Analysis of SARS-CoV-2 mRNA Vaccinations

MBL International provides QuickSwitch™ Tetramers for the Quant Analysis of SARS-CoV-2 mRNA Vaccinations.

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Cervical cancer is the fourth most common cancer affecting women: Antigen-Specific Detection of HPV and HSV 

Cervical cancer is the 4th most prevalent cancer among women, and the 7th most common cancer. MBLI provides HPV-related tetramers for use in research.

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Apoptosis - Roadway to Pathogenesis and Treatment

MBL International offers antibodies, recombinant proteins, kits and assays to assist in the detection and analysis of different apoptotic molecules.

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Rapid and Reliable Custom Tetramer Generation for T-Cell Staining

MBLI QuickSwitch™ kit technology aims to replicate the immune response by mimicking peptide exchange on an MHC molecule.

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HA-tags: Better Understanding of Localisation, Expression and Purification of Target Proteins

MBLI offers antibodies & kits for epitope tag experiments. These products provide high sensitivity for purification experiments & other applications.

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Defined Immune Response Tracking in Mice: OVA MHC Tetramers

T cell-dependent OVA antigen is used as a model protein for studying antigen-specific immune responses in mice. MBL has OVA related tetramer products.

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Streamline the detection of CD4 T cells with QuickSwitch™ Class II Quant Tetramer Kits

Use QuickSwitch™ Class II Quant Tetramer to investigate peptide-MHC binding affinities & conclude with your specialised CD4+ T cell detection reagent!

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The Importance of In Vivo Isotype Controls in Advancing Therapeutic Drug Development

MBLI offer a webinar that addresses the FAQs they receive from researchers. They have also included information to assist in designing in vivo studies.

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Protective Role of Invariant Natural Killer T (iNKT) cells 

CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells

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Introducing MBLI's easy-to-use Western Reagents

MBL Western Substrates are highly sensitive & compatible chemiluminescent substrates for use with immunoblots with HRP-conjugated secondary antibodies

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2023 Advancements in Research with QuickSwitch™ Custom Tetramer Kits

Here are the highlights of some of the influential publications that have utilised MBLI QuickSwitch™ Tetramer Kits in 2023.

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Respiratory Syncytial Virus (RSV): Continued Research for the Most Prevalent Respiratory Virus Among Children

RSV is a significant respiratory virus in young children, & is the primary cause of hospitalisations, particularly bronchiolitis & pneumonia.

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