Nordic MuBio

Mouse anti Human Proximal Nephrogenic Renal Antigen cln PN-15 (66.4.C2)

Product Code:
 
EXA-X1234M
Product Group:
 
Primary Antibodies
Supplier:
 
Nordic MuBio
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
66.4.C2
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X1234M100 ug£316.00
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Further Information

Applications Description:
This antibody can be used for the differential diagnosis of carcinomas by Western blotting and immunohistochemistry on frozen and paraffin-embedded tissues. Protease digestion prior to antibody incubation enhances staining of tissue sections. Optimal concentration should be evaluated by serial dilutions.
Background:
This antibody reacts with a glycoprotein of 200 kDa present in proximal renal tubules. The antigen is a carbohydrate in nature and retained in formalin fixed paraffin embedded tissues. Other normal tissues that display the antigen include breast, parathyroid glands and epididymis. Among renal carcinomas, 93% of primary and 84% of metastatic carcinomas are positive for this antigen. Relatively few other tumor types are positive: breast cancers, teratocarcinomas and parathyroid adenomas.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Infectious Agents & Disease
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Paraffin Section Staining
Immunogen:
Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with renal cortical tissue extract and mouse myeloma cells
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Protein A/G Chromatography
Source:
Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with renal cortical tissue extract and mouse myeloma cells
UniProt:
Q16790

References

1. Yoshida, S.O. and Imam, A., 'Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas.' Cancer Res. 1989, 49, 1802-1809.

2. Piron, A., et al. 'In vitro demonstration of a mitogenic activity in renal tissue extracts during regenerative hyperplasia.' Am. J. Physiol. 1998, 274, F348-F357.