Nordic MuBio

Rabbit anti Human Calcium Channel

Product Code:
 
EXA-X1513P
Product Group:
 
Primary Antibodies
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X1513P100 ug£316.00
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  • Further Information
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Further Information

Applications Description:
This antibody can be used for Western blotting (5-10 ?g/ml). Optimal concentration should be evaluated by serial dilutions.
Background:
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA).
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the rat beta1 calcium channel conjugated to KLH
Positive Control:
Rat brain lysate
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Synonyms:
Voltage-Dependent L-Type Calcium Channel, ?1 subunit
UniProt:
Q02641

References

1. Powers, P.A., et al. 'Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene.' J. Biol. Chem. 1992, 267, 22967-22972.

2. Collin, T., et al. 'Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit form normal human heart.' Circ. Res. 1993, 72, 1337-1344.

3. Fukuda, K., et al. 'Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.' Neurosci. Lett. 1996, 217, 13-16.

4. Hogan, K., et al. 'Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels.' Neurosci. Lett. 1999, 277, 111-114.