Further Information
TNFRSF1A, tumor necrosis factor-alpha receptor, tumor necrosis factor receptor type 1, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor binding protein 1, TNF-R-I, TNF-RI, TNFR-I, TNFR60, TNF-R55, TNFR55, TNF-R1, TNFR1, TNF-R, TNFAR, TBP1, p60, p55-R, p55, MGC19588, FPF, CD120a
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 22-211 of human TNFR1 (NP_001056.1).
7132
tumor necrosis factor receptor superfamily, member 1A
TNFRSF1A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 56kDa
Affinity purification
Apoptosis, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Neuroscience, Signal Transduction
P19438
Optimal dilutions for each application to be determined by the researcher.