Further Information
NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PXR (NP_071285.1).
8856
nuclear receptor subfamily 1, group I, member 2
NR1I2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 49kDa
Affinity purification
Cancer, Cell Cycle, Growth Factors, Signal Transduction, Transcription
O75469
Optimal dilutions for each application to be determined by the researcher.
