Further Information
LAR, Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related, LAR, Receptortype tyrosineprotein phosphatase F, LAR protein, Leukocyte antigen related
WB: 1:500 - 1:2000
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 30-190 of human PTPRF (NP_569707.2).
5792
protein tyrosine phosphatase, receptor type, F
PTPRF
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 150kDa
Affinity purification
Cancer, Neuroscience, Signal Transduction
P10586
Optimal dilutions for each application to be determined by the researcher.
