Further Information
pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2), ARNO, CTS18, CTS18.1, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, ARF exchange factor, ARF nucleotide-binding site opener, cytohesin 2, pleckstrin homology, Sec7 and coiled-coil domains 2-like, PSCD2
WB: 1:500 - 1:2000
IF: 1:50 - 1:100
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human CYTH2 (NP_059431.1).
9266
cytohesin 2
CYTH2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 47kDa
Affinity purification
Cell Cycle, Signal Transduction
Q99418
Optimal dilutions for each application to be determined by the researcher.