Further Information
TOK-1, TOK1, BRCA2 and CDKN1A-interacting protein, BCCIPalpha, BCCIPbeta, BRCA2 and Cip1/p21 interacting protein, TOK-1alpha, TOK-1beta, cdk inhibitor p21 binding protein, p21- and CDK-associated protein 1, protein TOK-1
WB: 1:500 - 1:2000
IHC: 1:100 - 1:200
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1).
56647
BRCA2 and CDKN1A interacting protein
BCCIP
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 50kDa
Affinity purification
Cancer, Cell Cycle, Chemokines & Cytokines, Immunology
Q9P287
Optimal dilutions for each application to be determined by the researcher.