NSJ Bioreagents

Nucleophosmin Antibody (Npm1)

Product Code:
 
NSJ-F52273
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1042CT5.2.1
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Aliquot the Nucleophosmin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
1 / 2
Immunohistochemical analysis of paraffin-embedded human thymus using Nucleophosmin antibody at 1:25 dilution.~
2 / 2
Nucleophosmin antibody western blot analysis in 1) HeLa, 2) Jurkat, 3) MCF-7, and 4) mouse NIH3T3 lysate
❮❯

Immunohistochemical analysis of paraffin-embedded human thymus using Nucleophosmin antibody at 1:25 dilution.~
Nucleophosmin antibody western blot analysis in 1) HeLa, 2) Jurkat, 3) MCF-7, and 4) mouse NIH3T3 lysate

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CodeSizePrice
NSJ-F52273-0.08ML0.08 ml£260.00
Quantity:
NSJ-F52273-0.4ML0.4 ml£502.00
Quantity:
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Further Information

Application Details :
IHC (Paraffin): 1:25,Western blot: 1:1000
Application Note:
Titration of the Nucleophosmin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Nucleophosmin is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
Purified His-tagged protein was used to produced this monoclonal Nucleophosmin antibody.
Limitation:
This Nucleophosmin antibody is available for research use only.
Purity:
Purified
Species Reactivity :
Human
Uniprot #:
P06748