NSJ Bioreagents

EGLN1 / PHD2 Antibody

Product Code:
 
NSJ-V8026
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
366G/76/3
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store the EGLN1 / PHD2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
1 / 1
SDS-PAGE analysis of purified, BSA-free EGLN1 antibody (clone 366G/76/3) as confirmation of integrity and purity.
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SDS-PAGE analysis of purified, BSA-free EGLN1 antibody (clone 366G/76/3) as confirmation of integrity and purity.

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CodeSizePrice
NSJ-V8026-20UG20 ug£264.00
Quantity:
NSJ-V8026-100UG100 ug£534.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details :
Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml
Application Note:
Optimal dilution of the antibody should be determined by the researcher.
Description:
366G/76/3 recognises human prolyl hydroxylase 2 (PHD2), a 46kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
Format :
Purified
Formulation :
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
Amino acids 1-24 of human PHD2/EGLN1 were used as the immunogen for the EGLN1 antibody.
Limitation:
This EGLN1 / PHD2 antibody is available for research use only.
Localization:
Cytoplasmic
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
Q9GZT9