NSJ Bioreagents

PAX5 Antibody

Product Code:
 
NSJ-F41639
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Aliquot the PAX5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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PAX5 antibody western blot analysis in Ramos lysate
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PAX5 antibody flow cytometric analysis of Ramos cells (right histogram) compared to a negative control (left histogram)
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PAX5 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue

PAX5 antibody western blot analysis in Ramos lysate
PAX5 antibody flow cytometric analysis of Ramos cells (right histogram) compared to a negative control (left histogram)
PAX5 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue

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CodeSizePrice
NSJ-F41639-0.08ML0.08 ml£260.00
Quantity:
NSJ-F41639-0.4ML0.4 ml£502.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details :
Western blot: 1:1000,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:10-1:50
Application Note:
Titration of the PAX5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 178-207 from the human protein was used as the immunogen for this PAX5 antibody.
Limitation:
This PAX5 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Species Reactivity (Predicted):
Mouse
Uniprot #:
Q02548