NSJ Bioreagents

Phospho-TSC2 Antibody (pS1096)

Product Code:
 
NSJ-F48775
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Dot Blot
  • Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
 
Aliquot the phospho-TSC2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Dot blot analysis of phospho-TSC2 antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
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Dot blot analysis of phospho-TSC2 antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.

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CodeSizePrice
NSJ-F48775-0.08ML0.08 ml£260.00
Quantity:
NSJ-F48775-0.4ML0.4 ml£502.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Dot blot: 1:500
Application Note:
Titration of the phospho-TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
This phospho-TSC2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1096 of mouse TSC2.
Limitation:
This phospho-TSC2 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Mouse
Uniprot #:
Q61037