NSJ Bioreagents

METTL14 Antibody (N-Terminal Region)

Product Code:
 
NSJ-F54217
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the METTL14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of human 1) HL60, 2) A431, 3) Jurkat and 4) mouse NIH3T3 cell lysate with METTL14 antibody at 1:2000. Predicted molecular weight ~52 kDa.
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Western blot testing of human 1) HL60, 2) A431, 3) Jurkat and 4) mouse NIH3T3 cell lysate with METTL14 antibody at 1:2000. Predicted molecular weight ~52 kDa.

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CodeSizePrice
NSJ-F54217-0.05ML0.05 ml£260.00
Quantity:
NSJ-F54217-0.2ML0.2 ml£502.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Western Blot: 1:2000
Application Note:
The stated application concentrations are suggested starting points. Titration of the METTL14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
N6-adenosine-methyltransferase subunit METTL14 is an N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs.
Format :
Antigen affinity purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 2-36 from the N-terminal region of the human protein was used as the immunogen for the METTL14 antibody.
Limitation:
This METTL14 antibody is available for research use only.
Purity:
Peptide affinity purified
Species Reactivity :
Human, Mouse
Species Reactivity (Predicted):
Bovine
Uniprot #:
Q9HCE5