TAP2 Antibody / ABCB3 (N-Terminal Region)

WB: 1:1000-1:2000

The stated application concentrations are suggested starting points. Titration of the TAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 100-134 from human TAP2 was used as the immunogen for the TAP2 antibody.

This TAP2 antibody is available for research use only.

Antigen affinity

Human

Q03519