DERL1 Antibody / Derlin 1

Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE): 1:50-1:100, Western blot: 1:500-1:1000

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.

This Derlin 1 antibody is available for research use only.

Cytoplasmic

Antigen affinity purified

Human, Mouse

Q9BUN8