TargetMol

yangonin

Product Code:
 
TAR-T3S0738
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S0738-1mg1mg£122.00
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TAR-T3S0738-5mg5mg£181.00
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TAR-T3S0738-1mL1 mL * 10 mM (in DMSO)£220.00
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TAR-T3S0738-10mg10mg£245.00
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TAR-T3S0738-25mg25mg£365.00
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TAR-T3S0738-50mg50mg£507.00
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TAR-T3S0738-100mg100mg£691.00
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Further Information

Bioactivity:
1. Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. 2. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.
CAS:
500-62-9
Formula:
C15H14O4
Molecular Weight:
258.273
Pathway:
NF-κb; GPCR/G Protein; Autophagy
Purity:
0.9955
SMILES:
COc1ccc(C=Cc2cc(OC)cc(=O)o2)cc1
Target:
Cannabinoid Receptor; NF-κB; Autophagy

References

Ma J, et al. Yangonin blocks tumor necrosis factor-?-induced nuclear factor-?B-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54. Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95. Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.