TargetMol

Corylifol A

Product Code:
 
TAR-T4S0145
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S0145-1mg1mg£108.00
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TAR-T4S0145-5mg5mg£148.00
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TAR-T4S0145-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T4S0145-10mg10mg£195.00
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TAR-T4S0145-25mg25mg£281.00
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TAR-T4S0145-50mg50mg£383.00
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TAR-T4S0145-100mg100mg£531.00
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Further Information

Bioactivity:
1. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ? 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.
CAS:
775351-88-7
Formula:
C25H26O4
Molecular Weight:
390.47
Pathway:
JAK/STAT signaling; Stem Cells; Metabolism
Purity:
0.9719
SMILES:
CC(C)=CCCC(C)=CCc1cc(ccc1O)-c1coc2cc(O)ccc2c1=O
Target:
hCE; STAT; UGT

References

Chen J, Zhou X, Fu L, et al.Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro[J]. Pharmaceuticals, 2023, 16(5): 767..Pharmaceuticals.2023, 16(5): 767. Li, N., Miao, J., Li, J., Zhao, Y., Li, H., & Dai, Y. et al. (2017). Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase. Carbohydrate Research, 446-447, 61-67. doi: 10.1016/j.carres.2017.05.002