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Further Information
CHIR-99021 is a GSK-3α/β inhibitor (IC50: 10/6.7 nM).
CHIR-99021 is a highly selective inhibitor of GSK-3α/β, which are regulators of the Wnt signaling pathway. By inhibiting GSK-3α/β, CHIR-99021 promotes the activation of the Wnt signaling pathway, thereby influencing the self-renewal and differentiation of stem cells. For example, human pluripotent stem cell (hPSC)-derived organoids such as Heart Forming Organoids (HFOs) represent a complex, highly structured in vitro model of early heart, gut, and vascular system development. These organoids are commonly used in teratogenic research, gene function analysis, and drug discovery studies. CHIR-99021 and IWP2 (Catalog No. T2702) are typically used during the establishment of this model for cell differentiation.
As research progresses, scientists have found that CHIR-99021 significantly enhances the quantity and functionality of stem cells, showing promising applications across various stem cell types. The scope of CHIR-99021's applications continues to expand. Apart from its use in the field of stem cells, CHIR-99021 also demonstrates potential therapeutic value in neurodegenerative diseases, tumors, and metabolic disorders. In neurodegenerative diseases, CHIR-99021 can inhibit the generation and aggregation of beta-amyloid proteins, thereby slowing the progression of conditions like Alzheimer's disease. In the field of tumors, CHIR-99021 can modulate tumor cell proliferation and apoptosis, inhibiting tumor growth and metastasis. Additionally, CHIR-99021 can improve symptoms of metabolic disorders such as diabetes and obesity, promoting metabolic balance in the body.
252917-06-9
C22H18Cl2N8
CHIR-99021, also known as Laduviglusib or CT99021, is a highly selective inhibitor of GSK-3α/β (Glycogen synthase kinase 3), with IC50 values of 10 nM and 6.7 nM, respectively. It is also an effective activator of the Wnt/β-catenin signaling pathway. Additionally, CHIR-99021 can induce autophagy and enhance self-renewal in mouse and human embryonic stem cells.
465.34
Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
0.9891
type 2 diabetes, Alzheimer's disease, inflammation, cancer, addiction, and bipolar disorder.
Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
GSK-3; Wnt/beta-catenin; Autophagy