TargetMol

Brevilin A

Product Code:
 
TAR-T4672
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4672-1mg1mg£148.00
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TAR-T4672-5mg5mg£252.00
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TAR-T4672-1mL1 mL * 10 mM (in DMSO)£270.00
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TAR-T4672-10mg10mg£383.00
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TAR-T4672-25mg25mg£587.00
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TAR-T4672-50mg50mg£781.00
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TAR-T4672-100mg100mg£1,026.00
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TAR-T4672-500mg500mg£2,022.00
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Further Information

Bioactivity:
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour
CAS:
16503-32-5
Formula:
C20H26O5
Molecular Weight:
346.41
Pathway:
Autophagy; Microbiology/Virology; Chromatin/Epigenetic; Stem Cells; JAK/STAT signaling; Angiogenesis; Apoptosis
Purity:
1
SMILES:
C/C=C(C)C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
Target:
Apoptosis; Anti-infection; JAK; STAT; Autophagy

References

Antiprotozoal activities of Centipeda minima. Phytother. Res., 1994, 8(8):436-8.